Which type of immune cells are predominantly activated in the spleen?

The activation of immune cells in the spleen primarily involves T cells and B cells, making this the correct choice. The spleen plays a crucial role in the immune response, particularly in responding to blood-borne pathogens. It is divided into two main regions: the red pulp and the white pulp. The white pulp contains clusters of lymphocytes, including T cells and B cells.

B cells are primarily responsible for antibody production, and they can become activated in response to antigens present in the blood. When B cells encounter their specific antigens in the spleen, they can differentiate into plasma cells that produce antibodies. Similarly, T cells, including helper T cells and cytotoxic T cells, also become activated in the vicinity of the white pulp, where they respond to antigens and help orchestrate the immune response.

In contrast, natural killer cells are primarily associated with the innate immune response and do not predominantly reside or get activated in the spleen in the same manner as T and B cells. Regulatory cells, including regulatory T cells, are important for maintaining immune tolerance but are not the main focus of activation in the spleen. Eosinophils are primarily involved in responses to parasitic infections and allergic reactions and are more commonly found in tissues rather