Which immune cell type plays a key role in regulating allergic responses?

Basophils are a type of white blood cell that play a crucial role in regulating allergic responses and inflammatory processes. They are part of the innate immune system and are typically found in tissues, especially in areas such as the skin and respiratory tract where allergens often enter.

When exposed to allergens, basophils release inflammatory mediators like histamine, leukotrienes, and prostaglandins. These substances contribute to the symptoms of allergies, such as itching, swelling, and bronchoconstriction. The degranulation of basophils is particularly important in the early phases of allergic reactions and is key to amplifying the immune response.

In addition to their role in immediate hypersensitivity reactions, basophils also produce cytokines that help recruit other immune cells, further regulating and exacerbating allergic responses. Their interaction with other immune cells, such as T cells, can influence the type of immune response initiated, making them pivotal players in both the initiation and regulation of allergy-related immune processes.