Which cells are included in the MHC class II presentation?

MHC class II molecules play a crucial role in the immune system, particularly in presenting antigens to CD4+ T helper cells. These molecules are typically expressed on professional antigen-presenting cells (APCs), which play a key role in activating the adaptive immune response.

B cells are indeed one of the primary types of cells that express MHC class II molecules. They are capable of capturing and presenting antigens to T helper cells, which is essential for T cell activation and subsequent antibody production. This interaction is pivotal for orchestrating a more effective immune response against pathogens, as it links the innate and adaptive branches of immunity.

Other cell types, such as dendritic cells and macrophages, also express MHC class II and present antigens to CD4+ T cells. However, the question specifically asks about which cells are included in MHC class II presentation, and B cells are especially notable for their role in this process, as they not only present antigens but also produce antibodies in response to T cell help.

In contrast, T cells themselves do not present antigens in association with MHC class II molecules because they primarily recognize antigens presented by other cells. Natural killer cells are part of the innate immune system and primarily interact with MHC