What role do basophils primarily play in the immune system?

Basophils primarily play a crucial role in the immune system by participating in allergic reactions. These cells are a type of granulocyte and are known for their ability to release histamine and other mediators in response to allergens. When the immune system encounters an allergen, basophils become activated and release these substances, which leads to the symptoms commonly associated with allergies, such as inflammation, redness, and swelling.

In addition to their role in allergies, basophils also play a part in defense against parasites, particularly during helminth infections. Their involvement in the inflammatory response can help recruit other immune cells to the site of an allergenic challenge or infection. This specificity in function distinguishes basophils from other immune cells that may have broader roles, such as responding to bacterial infections or regulating immune cell activity.

This focus on allergic responses is critical for understanding how the immune system interacts with various stimuli and how certain cell types are specialized for particular functions within the broader immune response.