Are alpha 2-macroglobulins protease inhibitors that trap pathogens?

Alpha 2-macroglobulins are indeed protease inhibitors that play a role in the immune response by trapping pathogens. They function by binding to proteases, which are enzymes that can degrade proteins, including those present on the surface of pathogens. When alpha 2-macroglobulin encounters a protease, it undergoes a conformational change that allows it to form a stable complex with the enzyme. This binding not only inhibits the activity of the protease but also facilitates the clearance of the entire complex from the circulation by immune cells.

The role of alpha 2-macroglobulins extends to recognizing and neutralizing various pathogens, thereby contributing to the innate immune response. By trapping and inhibiting these enzymes, they help to prevent tissue damage and promote the effective clearance of pathogens by immune cells. Thus, the assertion that alpha 2-macroglobulins act as protease inhibitors that trap pathogens is accurate.